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This process is primarily triggered by cumulative oxidative stress, DNA damage, and telomere attrition, which activate key pathways such as p53/p21 and p16^INK4a/Rb, leading to permanent cell cycle arrest (Loeser, 2009)

CONCLUSION The relationship between vitamin B12 deficiency and chronic metformin use is well established, but the underlying mechanisms remain poorly understood

Such as PD-1 ligand (PD-L1) within TME, the expression of immune checkpoint molecules has been shown to predict response to ICIs in some but not all cases [149, 150]

The 1,4-adduct 3a showed a noteworthy shorter-wavelength shift of the fluorescence maximum from the 574 nm of 2a to 521 nm, along with a change of florescence color from yellow to green